Abstract
Dry Powders for Pulmonary Delivery of Peptides and Proteins
Highlights
Recent advances in biotechnology have made it possible to use macromolecules such as peptides and proteins as therapeutic agents
This section summarizes the histological features of the lungs, drug permeability through the lung epithelium, the metabolism of proteins and peptides in lung tissue, and the safety of peptides and proteins administered through the lungs
These results suggest that drug absorption is more rapid in the alveolar region than in the tracheobronchial region of the lungs [24]
Summary
Recent advances in biotechnology have made it possible to use macromolecules such as peptides and proteins as therapeutic agents. At this time intravenous, intramuscular, and subcutaneous injections are the practical routes for administering such macromolecules. Recombinant human deoxyribonuclease (rhDNase) is the first protein approved for inhalation therapy [1]. This review will focus on the dry powder peptides and proteins for inhalation. The success of inhalation therapy with dry powders is determined by the active ingredient’s biological aspects, by the physicochemical aspects of formulation, and by inhaler performance (Fig. 1). Factors determining successful inhalation therapy with dry powders. Biological and physicochemical aspects of inhalation therapy with dry powder peptides and proteins. Extensive reviews on inhalers are available elsewhere [8, 9]
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