Abstract
Normal, human diploid skin fibroblasts (GM-10) were grown in culture and the changes in the mean cellular, nuclear and nucleolar dry mass and area were monitored simultaneously at regular intervals until the last passage. The results which were analyzed statistically showed that all measures increased during aging in vitro with a most striking surge for all values from passage 29 to 31. The area measures of the cell, nucleus and nucleosis were well correlated with the measures of dry mass for the same structures. The results are discussed and possible reasons for the findings are offered.
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