Drug/Medical Device Combination Products with Stimuli-responsive Eluting Surface

Abstract

Drug-eluting medical devices are designed to improve the primary function of the device and at the same time offer local release of drugs which otherwise might find it difficult to reach the insertion/implantation site. The incorporation of the drug enables the tuning of the host/microbial responses to the device and the management of device-related complications. On the other hand, the medical device acts as platform for the delivery of the drug for a prolonged period of time just at the site where it is needed and, consequently, the efficacy and the safety of the treatment, as well as its cost-effectiveness are improved. This chapter begins with an introduction to the combination products and then focuses on the techniques available (compounding, impregnation, coating, grafting of the drug or of polymers that interact with it) to endow medical devices with the ability to host drugs/biological products and to regulate their release. Furthermore, the methods for surface modification with stimuli-responsive polymers or networks are analyzed in detail and the performance of the modified materials as drug-delivery systems is discussed. A wide range of chemical-, irradiation- and plasma-based techniques for grafting of brushes and networks that are sensitive to changes in temperature, pH, light, ionic strength or concentration of certain biomarkers, from a variety of substrate materials, is currently available. Although in vivo tests are still limited, such a surface functionalization of medical devices has already been shown useful for the release on-demand of drugs and biological products, being switchable on/off as a function of the progression of certain physiological or pathological events (e.g. healing, body integration, biofouling or biofilm formation). Improved knowledge of the interactions among the medical device, the functionalized surface, the drug and the body are expected to pave the way to the design of drug-eluting medical devices with optimized and novel performances.