Abstract
Renal medullary necrosis has been produced in rats with the injection of 2-bromo-ethylamine hydrobromide, and the amount of daily urinary output and fluid intake has been measured. In addition, the enlarged adrenal glands that develop in these rats have been quantitatively analyzed, and examined by light microscopy.The rats with renal medullary necrosis develop a prominent degree of polyuria and polydipsia, and drink a large amount of 0.9% sodium chloride solution. The enlarged adrenal glands show an increase in width of the zona fasciculata, and their weight progressively increases until the sixth day of the experiment.In conclusion, the renal medullary necrosis induces a profound derangement of the homeostatic function.
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