Abstract
1-Methyl-3-isobutylxantine (MIX) caused rapid increases in cytoplasmic and nuclear ornithine decarboxylase (ODC) activity as well as increases in RNA polymerases I and II. MIX also significantly increased labeling of nuclear proteins with [ 3H]-leucine while causing only a slight rise in the labeling of the cytoplasm. Cycloheximide prevented the MIX-induced increases in cytoplasmic ODC, RNA polymerases I and II, and radioactive labeling of cytoplasmic and nuclear proteins. Cycloheximide did not prevent the MIX-induced change in nuclear ODC. These data suggest that cytoplasmic ODC migrated in to the nucleus after MIX treatment but this migration was not correlated with increased RNA polymerase activity.
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