Drug utilization evaluation of olanzapine and assessment of adverse drug reactions associated in psychotic patients in a Tertiary Care Hospital

Abstract

Objectives: To review the drug utilization and evaluation pattern of olanzapine and assessment of adverse drug reaction associated in psychotic patients in a tertiary care hospital. Methodology: A prospective Observational study was conducted in Department of Psychiatry, MVJ Medical College and Research Hospital, Bangalore, South India. Study was conducted for 6 months in In-patients who are diagnosed as suffering from psychosis which includes schizophrenia, delusional disorders, schizo-affective disorders, acute and transient psychosis and BPAD as per ICD 10 criteria. The utilization pattern of olanzapine therapy were assessed using case record forms with overall demographic data information was collected and ADR is assessed using standard scales. Result: Among 108 patients enrolled into the study 68 patients were under olanzapine therapy and rest were under other antipsychotics. A total of 68 patients olanzapine therapy patients out of which 51%were females and 49% were males. Majority of the patients belong to the age group of 28-37years and 18–27 years and 66% patients were married. Schizophrenia was found to be the common type of psychotic disorders with 63%. Even among the various psychotic disorders there was a slight female predominance. The hospitalization period was 12.43±8.4days. Majority of the patients had normal body mass index. Out of 68 patients 16 patients had switch over from olanzapine to other second-generation antipsychotics. Conclusion: This study has assessed for prescribing pattern of olanzapine in psychotic patients using a specially modified case reporting form. Olanzapine is most commonly prescribed antipsychotic compared to other antipsychotics for the treatment of paranoid schizophrenia and also in certain cases of bipolar affective disorder with mania or mixed episodes. Maximum patients were having paranoid schizophrenia.