Abstract
Objective: To monitor drug utilization based adverse drug reactions (ADRs) of antihypertensive agents prescribed in Al-Quwayiyah general hospital, Saudi Arabia.Methods: An open, non-comparative, observational study was conducted on hypertensive patients attending the medicine outpatient department of Al-Quwayyah general hospital, Al-Quwayyah, Saudi arabia. Data were collected by conducting patient interviews. Data were captured for adverse drug reaction monitoring based on Narinjo scale and WHO format.Results: 25 ADRs were observed out of 212 hypertensive patients. Incidence was found to be higher in patients more than 40 y age, and females experienced more ADRs (n = 16, 7.54%) than males, 9 (4.62%). Combination therapy was associated with more number of ADRs (64.0%) as against monotherapy (36.0%). Calcium channel blockers were found to be the most frequently associated drugs with ADRs (n = 8), followed by diuretics (n = 6), and β-blockers (n = 5). Among individual drugs, amlodipine was found to be the commonest drug associated with ADRs (n = 8), followed by torasemide (n = 4). ADRs associated with the central nervous system was found to be the most frequent (48.0%) followed by musculoskeletal complaints (20.0%) and respiratory system disorders (16.0%).Conclusion: ADRs were experienced by taking the antihypertensive drugs prescribed in Al-Quwayyah general hospital, Saudi arabia. The findings would be useful for physicians in rational prescribing. Calcium channel blockers were found to be the most frequently associated drugs with ADRs.
Highlights
Hypertension is the most common cardiovascular disease and it has been defined arbitrarily as a systolic blood pressure greater than 140 mm Hg or a diastolic pressure greater than 90 mm Hg [1]
A total of 212 hypertensive patients visited Al-Quwayyah general hospital
A total of 25 adverse drug reactions (ADRs) were observed in 212 hypertensive patients in which 115 male and 97 female were taken for study
Summary
Hypertension is the most common cardiovascular disease and it has been defined arbitrarily as a systolic blood pressure greater than 140 mm Hg or a diastolic pressure greater than 90 mm Hg [1]. The world health organization (WHO) has estimated one in every eight death globally due to hypertension. It's an increase in hypertension approximately 1/4 of the Saudi Arabia population and has become an important health problem affecting a large number of Saudi people [2]. In 90-95% of cases of hypertension, there is no underlying medical illness to cause an increase in B. The etiology of essential hypertension tends to run in families, with hypertension being twice as common in families who have a hypertensive patient [3]
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