Abstract
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology.
Highlights
Animal models have been widely used in the field of pre-clinical testing and toxicity testing of drugs [1]
In preclinical drug development, using human cells to predict the toxicity of candidate compounds to improve the success rate of clinical trials is a topic that is being explored by almost all major pharmaceutical companies
The Food and Drug Administration (FDA) and drug regulatory agencies in other countries have already being focusing on organ-on-a-chip technology that has the potential to replace animal models in preclinical testing of drugs
Summary
Animal models have been widely used in the field of pre-clinical testing and toxicity testing of drugs [1]. To simulate the toxic effects of drug candidates on different cells, tissues, or organs of the human body, scientists have constructed many organ-on-a-chip models that simulate single or multiple organs, e.g., the liver [13]-, kidney [14]-, heart [15]-, nerves [16]-, and multi-organs-on-chips [17]. These models have been proven to have the potential to develop into new platforms for drug toxicity detection [18]. We will summarize the latest drug toxicity assessments based on organ chips
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
