Abstract
The review presents data on the involvement of the system of circulating and renal tissue natriuretic peptides in the mechanism that supports water-salt homeostasis and protects the kidney from damage of various etiologies, as well as the results obtained in assessing the clinical efficacy and safety of a new drug from vasopeptidase inhibitors LCZ696 (sacubitryl/valsartan) in patients with chronic kidney disease.
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