Abstract
Thalidomide was administered to pregnant rats by various routes without significantly interfering with embryonic development. The discrepancy between the effect of this drug in animals and human beings is discussed. The problem of applying the results of animal testing to the human is reviewed. A protocol for testing drugs for teratogenicity in animals is proposed as an initial standard for obtaining basic information about the effects of drugs on the embryo. Until drug testing becomes somewhat more sophisticated, our most reliable method of protecting the public from all the harmful effects of drugs is through strict clinical surveillance programs.
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