Drug targets found in translation

Abstract

Systems Biology Translating findings from preclinical animal models to human subjects is challenging, and it is even more so when different types of data are compared. Brubaker et al. developed a method to compare transcriptomic data from inflammatory bowel disease patients with proteomics data from a mouse model of the disease. Their analysis suggested that integrin signaling contributed to resistance to the antitumor necrosis factor antibody infliximab. Experimentally, inhibiting α1 integrin subunit signaling enhanced the ability of infliximab to suppress proinflammatory cytokine release from immune cells. Sci. Signal. 13 , eaay3258 (2020).