Abstract
AbstractThe central nervous system (CNS) is a sanctuary site and is protected by various barriers. These regulate brain homeostasis and the transport of endogenous and exogenous compounds by controlling their selective and specific uptake, efflux, and metabolism in the brain. Unfortunately, potential drugs for the treatment of most brain diseases are therefore often not able to cross these barriers. As a result, various drug delivery and targeting strategies are currently being developed to enhance the transport and distribution of drugs into the brain. Here we discuss briefly the biology and physiology of the blood-brain barrier (BBB) and the blood-cerebro-spinal-fluid barrier (BCSFB), and, in more detail, the possibilities for delivering large-molecular-weight drugs by local and global delivery and by viral and receptor-mediated nonviral drug delivery to the (human) brain.
Highlights
Infectious diseases of the nervous system: pathogenesis and worldwide impact Roberto Bruzzone, Monique Dubois-Dalcq, Georges E Grau, Diane E Griffin and Krister Kristensson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
Targeting strategies to the BBB are necessary to selectively and transport macromolecular drugs to the brain. This can be accomplished by exploiting receptormediated transport (RMT) systems at the blood-brain barrier
Macromolecular protein drugs can be directly linked to a carrier molecule that fits to a RMT system
Summary
Infectious diseases of the nervous system: pathogenesis and worldwide impact Roberto Bruzzone, Monique Dubois-Dalcq, Georges E Grau, Diane E Griffin and Krister Kristensson Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. . Many brain diseases (such as meningitis, encephalitis, multiple sclerosis (MS), stroke, brain tumors, epilepsy, Alzheimer's disease, AIDS related dementia, Parkinson's disease) are under treated or cannot be treated at all due to the presence of the barriers in the brain (blood-brain barrier, blood-cerebrospinal fluid barrier and the braincerebrospinal fluid barrier). The blood-brain barrier is facing the blood side and is the largest barrier for transport of macromolecular drugs from blood to brain. Targeting strategies to the BBB are necessary to selectively and transport macromolecular drugs to the brain.
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