Abstract
Breakthrough pain in cancer patients (BTP), also referred to as episodic or incident pain, occurs in a signif - icant proportion of patients with baseline pain (40–60%). It is characterized by rapid intensifying (within tens of seconds or a few minutes) and a strong intensity in the numerical rating scale always above 5 and a limited duration, usually up to about 60 minutes. The choice of the drug for the management of BTP in clinical practice should be based on a profound knowledge of pathophysiology of BTP and pharmacokinetic parameters of the drugs used .
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