Abstract
We found high prevalence rates of multidrug-resistant tuberculosis among retreatment patients (71.1%) and persons with new cases (8.0%) in Angola. These findings are of concern but should be interpreted with caution. A national drug-resistance survey is urgently needed to determine the actual prevalence of multidrug-resistant tuberculosis in Angola.
Highlights
We found high prevalence rates of multidrug-resistant tuberculosis among retreatment patients (71.1%) and persons with new cases (8.0%) in Angola
Isolates identified as Mycobacterium tuberculosis complex (MTBC) underwent drugsusceptibility testing with BD-MGIT-960 SIRE and PZA kits (Becton Dickinson Diagnostic Systems, Sparks, MD, USA)
Isolates that were resistant to >1 drug were subjected to drug-susceptibility testing for second-line TB drugs by using the BD-MGIT-960 SIRE system
Summary
We found high prevalence rates of multidrug-resistant tuberculosis among retreatment patients (71.1%) and persons with new cases (8.0%) in Angola. These findings are of concern but should be interpreted with caution. A national drugresistance survey is urgently needed to determine the actual prevalence of multidrug-resistant tuberculosis in Angola. Before the start of treatment, we collected sputum specimens from all case-patients and provided them to the Mycobacteriology Unit (a World Health Organization Supranational TB Reference Laboratory) at Vall d’Hebron University Hospital in Barcelona, Spain, for culture and drug-susceptibility testing. Isolates identified as Mycobacterium tuberculosis complex (MTBC) underwent drugsusceptibility testing with BD-MGIT-960 SIRE and PZA kits (Becton Dickinson Diagnostic Systems, Sparks, MD, USA). We calculated the percentage of patients with resistance patterns to first- and second-line TB drugs on the basis of total number of cases and the total number of MDR TB cases, respectively
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