Drug Resistance in Oncology

Abstract

Part 1 Physiological resistance in solid tumours: angiogenesis and blood flow in solid tumours, Mark W. Dewhirst intra- and extracellular pH in solid tumours - influence on therapeutic response, Chang W. Song et al oxygenation of solid tumours, Peter W. Vaupel physiological resistance to the treatment of solid tumours, Rakesh K. Jain the role of oncogenes and tumour-suppressor genes in tumour angiogenesis, Lynn C. Yeoman the role of extracellular matrix in tumour invasion, metastasis and angiogenesis, Yves A. de Clerck and Walter E. Laug prediction of tumour treatment response using magnetic resonance spectroscopy, Paul Okunieff. Part 2 Biological resistance: heterogeneous clonal subpopulations in solid tumours, John T. Leith and Seth Michelson tumour subpopulation interactions and the expression of drug resistance, Gloria H. Heppner and Bonnie E. Miller therapeutic resistance in leukemia, William R. Waud and Daniel P. Griswold, Jr tumour site effects - central nervous system tumours, Henry S. Friedman and S. Clifford Schold, Jr in vivo resistance to antitumour alkylating agents, Beverly A. Teicher characteristics of the metastatic phenotype, Vincent J. Hearing. Part 3 Biochemical resistance: the role of glutathione and associated enzymes in the cellular response to radiation, peroxide and hydroperoxides, John E. Biaglow and Steve W. Tuttle metallothioneins in drug resistance, Nagahiro Saijo and John Stephen Lazo glutathione-S-transferases, Paul J. Ciaccio and Kenneth D. Tew oxazaphosphorine-specific acquired cellular resistance, Norman E. Sladek tumour-cell drug metabolism and drug resistance, Dennis E. Chapman and Garth Powis P-glycoprotein mediated multi-drug resistance, Bernard W. Futscher and William S. Dalton topoisomerase-related mechanisms of drug resistance, Daniel J. Fernandes et al. Part 4 The role of hormones, growth factors and oncogenes: acquisition of antioestrogen resistance in breast cancer, Robert Clarke and Marc E. Lippman chorionic gonadotropin - a tumouristatic and preventive agent in breast cancer, Irma H. Russo and J. Russo roles of TGF-B and FGF in tumour progression and metastastis, Danny R. Welch and Motowo Nakajima possible contribution of growth factors to the evolution of metastasis and de novo multidrug resistance in cancer, R. Kerbel and John R. MacDougall signal transduction and gene expression during mammalian cell response to ionizing radiation, Dennis E. Halllahan et al. Part 5 Clinical aspects of resistance: cancer chemotherapy - clinical evidence for drug resistance, Louis J. Ayash et al.