Drug repositioning using multiple gene expression profiles

Abstract

Drug repositioning using multiple gene expression profiles Chuo University’s Professor Y-h. Taguchi places focus on drug repositioning using multiple gene expression profiles. In my previous manuscripts (1-3), I introduced our studies of in silico drug repositioning using gene expression profiles. Nevertheless, in these studies, we could use the single gene expression profile to perform in silico drug repositioning. In this manuscript, the last one in this series, I introduce our recent study (4) in which we could use multiple gene expression profiles. Please see my previous article for more details about the in silico drug repositioning. (5)In the studies (1-3) introduced previously, I used tensor decomposition (TD) based unsupervised feature extraction (FE) (6,7), which was a mathematical/computational method for data processing and was recently implemented in Bioconductor packages. (8)