Drug release studies of titanium-based polyethylene glycol coating as a multifunctional substrate

Abstract

Thrombosis is the fundamental basis of a catastrophe of cardiovascular and other blood-reaching biomedical gadgets. Drug-eluting inserts for the nearby conveyance of anti-infection agents at clinical locales are believed to be promising in averting cardiovascular diseases. Titanium and its compositions have been generally utilized for blood-reaching biomedical devices because of its excellent biocompatibility; however, their blood compatibility should be improved. In this present study, titanium surface was modified with sodium hydroxide (NaOH) which generate hydroxyl group (–OH) groups thereby facilitating encapsulation of aspirin (200 mg) accompanied by the coating of various percentage (0.5%,1%,2%, 2.5% and 3% w/v) of polyethylene glycol (PEG) (MW-20,000). The drug release amount could be managed by the aspirin loading quantity and the PEG covering thickness. The measure of aspirin delivered in phosphate buffer solution (pH = 7.4) was resolved by utilizing a UV–Vis spectrophotometer. Aspirin was released continuously till 8 h for 0.5% to 2.5% PEG coating whereas for 2.5% and 3% PEG coating it has been released till 9 h. The aspirin release rate from the titanium substrates was performed by fitting the data to the Ritger–Peppas equation. The diffusional type n for a lower percentage of PEG coating indicates non-fickian transport because of swelling of the PEG layer whereas a higher percentage of PEG coating indicates the super case II transport mechanism in aspirin discharge. Therefore, the developed Ti-based substrates have the potential to elute drugs continuously thereby making them suitable for cardiovascular implants.