Abstract
Thermoresponsive poly(N-isopropylacrylamide-co-alkyl methacrylate) gels are capable of on-off regulation of drug release in response to external temperature changes because a gel surface skin formed with increasing temperature stops drug release from the gel interior. In this gel shrinking process, observation of bubble formation on the surface indicates that pressure is induced within the gel. This pressure may result in an outward convection of water
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