Drug Release Profiles and Disintegration Properties of Pectin Films.

Yoshifumi Murata,Kyoko Kofuji,Chieko Maida

doi:10.3390/ma12030355

Abstract

We assessed the disintegration profiles of the film dosage forms (FDs) prepared using pectin by measuring the amount of pectin dissolved from the films in a limited amount of aqueous medium. Furthermore, we used miconazole and dexamethasone as standard drugs and investigated the relationship between the disintegration rate of the FDs and the rate of drug release. We used two types of pectin in this study to develop thin films with a thickness of approximately 25–35 μm. The FDs gradually disintegrated in the aqueous medium, and the disintegration profile of the FDs differed depending on the types of pectin. In addition, the rate of disintegration of the film matrix affected the dissolution rate of the drug incorporated into the FD. Thus, our results show that FDs prepared using pectin are beneficial because of their high solubility in a limited amount of medium, and the rate of drug release from the FDs can be regulated by selecting a specific type of pectin or by altering the concentration of the film base.

Highlights

Film dosage forms (FDs) are excellent novel dosage forms for targeted drug delivery, becauseFDs rapidly swell and disintegrate in the bodily fluids and release the drug incorporated in the gel matrix of the FD [1,2,3,4,5,6]
4% pectin solution is shown in Table
FDs using different types of pectin aswe theinvestigated film base to determine the dissolution of the drugsdrugs in aWe limited amount of biological media

Summary

Introduction

Film dosage forms (FDs) are excellent novel dosage forms for targeted drug delivery, becauseFDs rapidly swell and disintegrate in the bodily fluids and release the drug incorporated in the gel matrix of the FD [1,2,3,4,5,6]. Film dosage forms (FDs) are excellent novel dosage forms for targeted drug delivery, because. The FD is a tool by which drugs can be delivered to local disease sites in the oral cavity [7,8]. The drug loading capacity of films is typically very low, FDs are easy to administer, in the case of patients who have difficulty in swallowing the conventional oral dosage forms. FDs prepared using natural polysaccharides such as sodium alginate or pullulan are beneficial for the treatment of localized conditions in the oral cavity [9,10]

Methods

Results

Conclusion