Abstract
A mathematical model is presented with which acetaminophen release curves from the gradient matrix system (GMS) with different geometries (slabs and spheres) can be described. Diffusion is considered the rate-controlling step in the release process. Position- and time-dependent diffusion coefficients account for the changes in the matrix structure due to the initial different loading concentrations and due to changes during the release process. Release of acetaminophen from slab model systems and from spherical systems can be adequately explained. Release curves of another model drug, mebeverine HCl, from planar GMS formulations are adequately predicted by the model.
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