Drug release from poly(vinyl alcohol) gel prepared by freeze-thaw procedure

Abstract

Abstract Poly(vinyl alcohol) (PVA) gel was prepared by a freeze-thaw cycle method. Sodium alginate or Pluronic L-62 was added for the control of drug release from PVA gel. The concentration dependence of sodium alginate or Fluronic L-62 on the drug release from PVA gel was evaluated according to the in vitro drug release procedure. The rheological strength of the PVA gel was measured with a rheometer. The morphological surface of PVA gel was observed by scanning electron microscopy. The physical strength of the gel increases with increasing sudium alginate concentration, while the drug release from the gel decreased with increasing sodium alginate or Pluronic L-62 concentration. It is apparent that these bases are available for a topical drug delivery system if the physical strength and the drug release from the gel can be controlled by adding sodium alginate or Pluronic L-62.