Abstract
The release rates of four commonly used drugs incorporated into a methyl acrylate-methyl methacrylate copolymer matrix were studied. The quantity released per unit surface area in single-surface release experiments was found to be proportional to the square root of time. The hardness of the tablet had little effect on the release-rate constant, although some tablets swelled and broke open before complete elution. Heating the tablets at 70° or exposing them to acetone vapor prevented the breaking and increased the release-rate constant. The effects of drug, drug concentration, compressional force, heating, and exposure to acetone vapor on the drug release-rate constant were analyzed in terms of matrix porosity and tortuosity. Drug release from tablets in which the total surface was exposed showed little deviation from linearity during the first 75% of the release when plotted against the square root of time.
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