Drug release and thermal properties of magnetic cobalt ferrite (CoFe2O4) nanocomposite hydrogels based on poly(acrylic acid-g-N-isopropyl acrylamide) grafted onto gum ghatti

Abstract

The aim of this study was to better understand the underlying drug release characteristics from Gg-cl-poly(NIPA-co-AA)/CoFe2O4 hydrogel containing metformin hydrochloride as model drug. Nanocomposite's hydrogel of gum ghatti free radical polymerization is used for the controlled release of metformin hydrogen chloride. Gum ghatti and CoFe2O4 nanoparticle dispersion were grafted by acrylic acid and N-isopropylacrylamide, employing graft copolymerization in the presence of N, N′–methylene-bis-acrylamide (MBA) as cross linker, and ammonium persulfate (APS) as initiator. The synthesized nanocomposites hydrogel was characterized using FTIR, SEM, TGA and DSC. Drugs were all released through diffusion in the hydrated matrix and polymer relaxation, irrespective of the drug solubility. In vitro drug release studies, at different pH values of pH = 4.0, 7.4 and 9.2 was employed. Drug release was influenced by the change of pH. The pH of 7.4 was considered as the optimized pH for maximum drug release. The nanocomposites hydrogel was loaded with metformin hydrochloride drug (100 mg) which is an antidiabetic drug to investigate the release profiles in PBS (pH 7.4). The effects of polymer level and initial drug loading on release depended on drug properties. Different models were studied for release kinetic studies which showed that the zero-order model suggested the best kinetics release studies in PBS (pH- 7.4) and showed sustained release. The kinetics of drug release were discovered to fit the Korsmeyer-Peppas model with n > 1, indicating a specific case II transport mechanism.