Abstract
Faciobrachial dystonic epileptic seizures usually precede the cognitive impairment associated with non-paraneoplastic limbic encephalitis secondary to voltage gated potassium channel complex (VGKC) antibodies, specifically to leucine-rich glioma inactivated 1 (LGI1) antibodies. Testing for VGKC-complex/LGI1 antibodies should be initiated with the recognition of faciobrachial dystonic seizures. This seizure subtype is refractory to treatment with the anti-epileptic drugs, but has been shown to be immunotherapy responsive. Early initiation of immunotherapy has been shown to fasten the time to recovery and also in minimizing the cognitive impairment.
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