Abstract
Drug reaction with eosinophilia and systemic (DRESS) syndrome is a severe systemic drug reaction with a reported mortality of 10% 5 . The estimated incidence of this syndrome ranges from 1 in 1000 to 1 in 10,000 drug exposures. The syndrome consists of a severe skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytes), and internal organ involvement. Here, we report a case of DRESS syndrome in a young male who presented with acute hepatitis.
Highlights
Zubin Dev Sharma, Vijayashree ShrirangGokhale, Sunit Lokwani, Arjun Lal KakraniDepartment of Medicine, Pad
The liver function tests on first day showed normal bilirubin levels with serum alanine transferase (ALT) of 157 IU/l and serum alkaline phosphtase (ALP) of 146 IU/l
The liver function tests were repeated and it showed an increase in ALT to 416 IU/l and ALP to 207 IU/l
Summary
Its features include severe skin rash associated with eosinophilia and systemic signs. The other note-worthy features are a delayed onset, usually 2-6 weeks after the initiation of drug therapy, and the possible persistence or aggravation of symptoms despite the discontinuation of the culprit drug. It is known as drug-induced hypersensitivity syndrome (DIHS). This case report highlights this syndrome and reflects the fact that all physicians and public health workers should be aware of this condition and need to identify this early in the form of rash, lymphadenopathy, and systemic signs
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