Drug- Phospholipid complex: A novel strategy for Lymphatic Filariasis treatment

Abstract

One of the most terrifying and ugly forms of filariasis to humans is lymphatic filariasis, where adult worms 7-10 cm long are found in the lymphatic system. Mf continues to multiply in the bloodstream of the host and translocates eventually to the LS. Filariasis-causing parasites block the human blood vessels and lymph nodes.The impasse allows fluid to drain into the terminus of the body and accumulate in tissues, causing severe swelling christened “lymphoedema”. LF is caused due Filariodiaceae family roundworms, often these are of three types (Wuchereria bancrofti, Brugia malayi and Brugia timori). All of these are handed down through Anopheles mosquitoes, Aedes mosquitoes and Culex pipiens. In worldwide over 90% of infectious diseases are caused by W. bancrofti. Several synthetic drugs are currently used to treat this disease. However these drugs are not as effective as killing adult worms and at the same time, some side effects are also seen. Conversely, plant actives ingredients complex with phospholipids to form nano-sized vesicles. As parasites live in the small intestine, nanometer-sized phyto vesicles can protect plant actives from deterioration in the stomach and easily reach their target and kill parasites without side effects.