Abstract
Permeation experiments were used to look for interactions between chlordiazepoxide and some common excipients, nutrients, and surfactants. No effect on the permeability coefficient was observed in the presence of starch, calcium hydrogen phosphate, gelatin, lactose, silica, sucrose, cholesterol, or porcine mucin. The coefficient increased in the presence of magnesium stearate and decreased with talc, sodium saccharin, skim milk, egg lecithin, beef albumin, egg albumin, polysorbate 80, cetrimonium bromide, and sodium lauryl sulfate, indicating an interaction of these substances with the drug.
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