Drug loading with supercritical carbon dioxide deposition on different silica derivatives: Carvedilol study

Abstract

Supercritical carbon dioxide is a promising method used to load water insouble drugs over different drug carriers. In this study, it is offered as an alternative method to load Carvedilol as a drug over different kinds of silica materials via supercritical carbon dioxide method. Two kinds of silica materials either spherical silica or MCM-41 were synthesized for this purpose. The characterization of the silica materials were carried out by using SEM, BET, XRD and FT-IR. Spherical silica materials were obtained by changing the synthesis temperatures as 70, 80 and 90 °C. The diameters of the synthesized silica structures were increased with an increase in the temperature. Among the other spherical silica materials, the best homogeneity was obtained for 70 °C synthesis temperature so it is chosen as drug carrier for spherical silica. BET surface areas of spherical silica and MCM-41 were 345.9 m2/g and 1057.0 m2/g, respectively. Carvedilol, poorly water souble drug, was loaded over spherical silica and MCM-41 and subsequently characterized by XRD, BET, SEM and FT-IR. Carvedilol was loaded over these silica materials. Drug loading over these materials were achieved as 42% and 26% for spherical silica and MCM-41, respectively.