Abstract
Mesoporous silica nanoparticles (MSN) have been widely developed as drug carriers for various drug models in various particle sizes. The morphology of MSN becomes one of the factors which influence drug loading ability. In this study, we investigated the correlation between particle size and surface charge toward the loading ability of MSN. We used various morphology of MSN included its zeta potential value and quercetin as a drug model. The result showed that both particle size and zeta potential value have a correlation toward loading ability. The smaller particle size has a higher loading ability. Meanwhile, the more negative surface charge has a higher loading ability. Additionally, we studied the drug release profile of MSN with different particle sizes. It showed that particle size and zeta potential value play important role in the drug release process to produce a typically-release profile.
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