Abstract
The 2 major factors affecting serum levels of the most commonly used cardiac glycoside digoxin, are patient compliance and the physical characteristics of the tablet; the latter is unimportant with the lipid soluble glycosides digitoxin and β-methyldigoxin. Several drugs interfere with the absorption of these cardiac glycosides from the gastrointestinal tract, either by adsorption, altering gut motility or other unknown mechanisms, but only mixtures containing kaolinpectin (and possibly some liquid antacids) are of potential clinical importance with tablets of a satisfactory dissolution profile.
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