Drug-induced liver injury associated with the use of nonsteroidal antiinflammatory drugs

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) are effective drugs used widely in clinical practice. NSAIDs are reversible inhibitors of cyclo-oxygenase, mainly used for the symptomatic relief of pain, whether rheumatologic, traumatic, infectious or episodic. However, the appointment of NSAIDs must be considered risk factors for side effects.Drug-induced liver injury associated with the use of NSAIDs does not have any specific manifestations and covers the symptoms that occur in a variety of liver lesions, from asymptomatic increase in transaminases to the development of fulminant liver failure. The need for early diagnosis, a difficult differential diagnostic search, and the absence of specific laboratory tests make this pathology quite difficult for a practicing physician. Treatment is based on the abolition of NSAIDs, which caused liver damage, and the appointment of symptomatic therapy. Preventive measures are reduced to compliance with the dose, multiplicity, ways of drug administration, the absence of polypragmasia, careful collection of medical history, analysis of risk factors before prescribing a drug and monitoring the patient in the dynamics.