Abstract
The study presented here was accomplished to assess the course of drug-induced liver diseases in patient’s rheumatoid arthritis receiving long-term methotrexate therapy. Diabetes mellitus was revealed as the most significant risk factor. The combination of diabetes mellitus with other risk factors (female sex) resulted in increased hepatic fibrosis, degree of hepatic encephalopathy and reduction of hepatic functions. The effectiveness and safety of ursodeoxycholic acid and cytolytic type-with S-Adenosyl methionine was also evaluated.Abbreviations13C-MBT: 13C-methacetin breath test; ALT: alanine aminotransferase; AP: alkaline phosphatase; AST: aspartic transaminase; DILD: drug-induced liver disease; DM: diabetes mellitus; HE: hepatic encephalopathy; HFM: hepatic functional mass; SAMe: S-Adenosyl methionine; UDCA: ursodeoxycholic acid.How to cite this articleIryna K, Helen M, Elena S. Drug-induced Liver Disease in Patients with Diabetes Mellitus. Euroasian J Hepato-Gastroenterol 2015;5(2):83-86.
Highlights
The clinical course of drug-induced liver disease (DILD) is still unpredictable
Cholestatic variant of DILD was dominant in group 3 (68.2%) (Graph 1)
Stage of fibrosis was higher in group 1 (Graph 2)
Summary
The clinical course of drug-induced liver disease (DILD) is still unpredictable. Drug-induced liver disease is a complex clinical problem because the spectrums of clinical and morphological variants are extremely diverse; the diagnosis is made by means of exclusion and there are no clear principles of therapy, except withdrawal of the drug. the physicians are aware of the possibility of hepatotoxic reactions to a variety of drugs, diagnosis is rarely formulated in clinical practice. Drug-induced Liver Disease in Patients with Diabetes Mellitus. The clinical course of drug-induced liver disease (DILD) is still unpredictable.
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