Drug-Induced Interstitial Lung Disease in a patient treated with a combination of palbociclib and fulvestrant

Abstract

A 59-year-old patient without a history of pulmonary disease presented with episodes of hemoptysis and acute respiratory failure after receiving fulvestrant and palbociclib for metastatic breast cancer. The High-Resolution chest CT demonstrated diffuse ground glass opacities, as well as diffuse smooth thickening of the interlobular septa and peribronchovascular interstitium, which are consistent with Drug-Induced Interstitial Lung Disease (DIILD). A few days of high-dose steroid therapy improved the patient's gas exchange from PaO2/FiO2 of 75 to 200. After hospital discharge, the oncologist resumed fulvestrant therapy, with no additional adverse events occurring during the subsequent follow-up.