Drug induced hypoplastic anemias and related syndromes.

Abstract

Article1 December 1953DRUG INDUCED HYPOPLASTIC ANEMIAS AND RELATED SYNDROMESEDWIN E. OSGOOD, M.D., F.A.C.P.EDWIN E. OSGOOD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-6-1173 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe object of this paper is to give a concise review of current concepts of the diagnosis and therapy of hypoplastic anemias and the closely related conditions known as erythrocytic hypoplasia, granulocytic hypoplasia and thrombocytic hypoplasia, and to outline briefly some of the unsolved problems relating to these disorders. A complete list of references to the literature on these subjects would be far longer than this article. The references cited have been chosen to guide the reader to readily accessible, recent articles, which in turn give references to earlier and sometimes more important papers.CELL DIVISION AND DIFFERENTIATIONTo understand...Bibliography1. Osgood EE: Culture of human marrow. Length of life of the neutrophils, eosinophils and basophils of normal blood as determined by comparative cultures of blood and sternal marrow from healthy persons, J. A. M. A. 109: 933-936 (Sept. 18) 1937. CrossrefGoogle Scholar2. OsgoodChu EEIT: The effect of nitrogen mustard on the granulocytic cell as observed by the marrow culture technic, Cancer Research 10: 98-102 (Feb.) 1950. MedlineGoogle Scholar3. Third, fourth and fifth reports of the committee for clarification of the nomenclature of cells and diseases of the blood and blood-forming organs, Am. J. Clin. Path. 20: 562-579 (June) 1950. CrossrefMedlineGoogle Scholar4. OsgoodWilhelm EEMM: Reticulocytes, J. Lab. and Clin. Med. 19: 1129-1135 (July) 1934. Google Scholar5. BrecherSchneiderman GM: A time-saving device for the counting of reticulocytes, Am. J. Clin. Path. 20: 1079-1083 (Nov.) 1950. CrossrefMedlineGoogle Scholar6. OsgoodSeaman EEAJ: The cellular composition of normal bone marrow as obtained by sternal puncture, Physiol. Rev. 24: 46-69 (Jan.) 1944. CrossrefGoogle Scholar7. Osgood EE: A simple technic for counting megakaryocytes, Proc. Soc. Exper. Biol. and Med. 69: 590-591 (Dec.) 1948. CrossrefMedlineGoogle Scholar8. HaddowTimmis AGM: Myleran in chronic myeloid leukaemia. Chemical constitution and biological action, Lancet 1: 207-208 (Jan. 31) 1953. CrossrefGoogle Scholar9. Galton DA: Myleran in chronic myeloid leukaemia. Results of treatment, Lancet 1: 208-213 (Jan. 31) 1953. CrossrefGoogle Scholar10. Seaman AJ: Cobalt and cortisone therapy of chronic erythrocytic hypoplasia, Am. J. Med. 13: 99 (July) 1952. CrossrefGoogle Scholar11. SeamanKoler AJRD: Acquired erythrocytic hypoplasia: a recovery during cobalt therapy. Report of two cases with review of the literature, Acta Haematologica 9: 153 (Mar.) 1953. CrossrefMedlineGoogle Scholar12. ReimanndeBerardinis HACT: Periodic (cyclic) neutropenia, an entity. A collection of sixteen cases, Blood 4: 1109-1116 (Oct.) 1949. CrossrefMedlineGoogle Scholar13. ReinholdNeumarkLightwoodCarter JDERCO: Familial hypoplastic anemia with congenital abnormalities (Fanconi's syndrome), Blood 7: 915-926 (Sept.) 1952. CrossrefMedlineGoogle Scholar14. Nelson MG: Purpura and pancytopenia complicating arsenotherapy, Brit. M. J. 1: 300-303 (Feb. 9) 1952. CrossrefMedlineGoogle Scholar15. LewisPutnamHendricksKerlanWelch CNLEFDIH: Chloramphenicol (Chloromycetin) in relation to blood dyscrasias with observations on other drugs. A special survey, Antibiotics and Chemotherapy 2: 601-608 (Dec.) 1952. Google Scholar16. WitkingWaid EME: Aplasia of the bone marrow during Mesantoin therapy. Report of a fatal case, J. A. M. A. 147: 757-759 (Oct. 20) 1951. CrossrefMedlineGoogle Scholar17. MarriottPeters HJHR: Blood dyscrasias secondary to gold: with a case of hypoplastic anemia cured by splenectomy, Ann. Int. Med. 32: 864-877 (May) 1950. LinkGoogle Scholar18. BestPaul WRJT: Severe hypoplastic anemia following anticonvulsant medication. Review of the literature and report of a case, Am. J. Med. 8: 124-130 (Jan.) 1950. CrossrefMedlineGoogle Scholar19. Kracke RR: Effect of sulfonamide drugs on blood, Am. J. Clin. Path. 14: 191-199 (Apr.) 1944. CrossrefGoogle Scholar20. Arnold GG: Aureomycin in staphylococcemia, complicating agranulocytosis following Tridione, J. Pediat. 36: 647-651 (May) 1950. CrossrefMedlineGoogle Scholar21. Custer RP: Aplastic anemia in soldiers treated with Atabrine (quinacrine), Am. J. M. Sc. 212: 211-224 (Aug.) 1946. CrossrefMedlineGoogle Scholar22. DameshekColmes WA: The effect of drugs in the production of agranulocytosis with particular reference to amidopyrine hypersensitivity, J. Clin. Investigation 15: 85-97 (Jan.) 1936. CrossrefMedlineGoogle Scholar23. (a) Council on Pharmacy and Chemistry, Reports of the Council: Dinitrophenol not acceptable for N. N. R., J. A. M. A. 105: 31-33 (July 6) 1935. (b) Imerman, S. W., and Imerman, C. P.: Dinitrophenol poisoning with thrombocytopenia, granulopenia, anemia and purpura complicated by lung abscess, J. A. M. A. 106: 1085-1088 (Mar. 28) 1936. Google Scholar24. Blackburn EK: Some observations on thiouracil neutropenia, with special reference to the sternal marrow, J. Clin. Path. 1: 295-301 (Nov.) 1948. CrossrefMedlineGoogle Scholar25. ShaneRileyLaurieBoutilier SJCJHM: The treatment of pulmonary tuberculosis with the thiosemicarbazones, Canad. M. A. J. 64: 289-293 (Apr.) 1951. MedlineGoogle Scholar26. Hilker AW: Agranulocytosis from tripelennamine (Pyribenzamine) hydrochloride, J. A. M. A. 143: 741-742 (June 24) 1950. CrossrefMedlineGoogle Scholar27. Pilcher RB: Agranulocytosis following treatment of Parkinson's syndrome with "diparcol" (diethyl-amino-ethyl-phenothiazine): a report of two cases, M. J. Australia 2: 295-299 (Aug. 15) 1950. CrossrefMedlineGoogle Scholar28. MillerPollockGriffith HRCGC: Fatal agranulocytosis resulting from a procaine derivative, J. Lab. and Clin. Med. 38: 850-857 (Dec.) 1951. MedlineGoogle Scholar29. StifelBurnheimer JLJC(a) : Agranulocytosis following administration of phenylbutazone (Butazolidin). Report of a case, J. A. M. A. 151: 555-556 (Feb. 14) 1953. (b) Bershof, E., and Oxman, A. C.: Agranulocytosis following use of phenylbutazone (Butazolidin). Report of a case, J. A. M. A. 151: 557-558 (Feb. 14) 1953. (c) Etess, A. D., and Jacobson, A. S.: Fatality due to agranulocytosis following use of phenylbutazone (Butazolidin), J. A. M. A. 151: 639-640 (Feb. 21) 1953. CrossrefMedlineGoogle Scholar30. Wraith DG (for F. Dudley Hart): Thrombocytopenic purpura associated with thyrotoxicosis and the administration of Sedormid, Proc. Roy. Soc. Med. 44: 922-923 (Nov.) 1951. MedlineGoogle Scholar31. SimpsonWilsonZimmerman TWEBSL: Fatal aplastic anemia occurring during anticonvulsant therapy: probable idiosyncrasy to Phenurone, Ann. Int. Med. 32: 1224-1228 (June) 1950. LinkGoogle Scholar32. CrokeBerry ARJW(a) : Agranulocytosis occurring during methimazole ("Tapazole") therapy, J. A. M. A. 148: 45-47 (Jan. 5) 1952. (b) Specht, N. W., and Boehme, E. J.: Death due to agranulocytosis induced by methimazole therapy, J. A. M. A. 149: 1010-1011 (July 12) 1952. CrossrefGoogle Scholar33. PreheimPeck DVME: Agranulocytosis due to amithiozone therapy, Am. Rev. Tuberc. 65: 339-343 (Mar.) 1952. MedlineGoogle Scholar34. Tyson TL: Agranulocytosis following pyrithyldione (Presidon) therapy, J. A. M. A. 141: 128-129 (Sept. 10) 1949. CrossrefMedlineGoogle Scholar35. MacArthur P: Serious idiosyncrasy to methoin, Lancet 1: 592-593 (Mar. 22) 1952. CrossrefMedlineGoogle Scholar36. Larson RK: The mechanism of quinidine purpura, Blood 8: 16-25 (Jan.) 1953. CrossrefMedlineGoogle Scholar37. WomackReiner CRCB(a) : Fatal aplastic anemia due to streptomycin: case report and brief review of pertinent literature, Ann. Int. Med. 34: 759-767 (Mar.) 1951. (b) Sacks, M. S., Bradford, G. T., and Spurling, C. L.: Aplastic anemia complicating streptomycin treatment of pulmonary tuberculosis, J. A. M. A. 147: 308-311 (Sept. 22) 1951. LinkGoogle Scholar38. SilvermanWorthen JJJF: Agranulocytosis in a patient treated with mercurial diuretics, J. A. M. A. 148: 200-203 (Jan. 19) 1952. CrossrefMedlineGoogle Scholar39. MoeschlinWagner SK: Agranulocytosis due to the occurrence of leukocyteagglutinins, Acta Haematologica 8: 29-41 (July-Aug.) 1952. CrossrefMedlineGoogle Scholar40. EvansTakahashiDuanePayneLiu RSKRTRC: Primary thrombocytopenic purpura and acquired hemolytic anemia. Evidence for a common etiology, Arch. Int. Med. 87: 48-65 (Jan.) 1951. CrossrefGoogle Scholar41. HarringtonMinnichHollingsworthMoore WJVJWCV: Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura, J. Lab. and Clin. Med. 38: 1-10 (July) 1951. MedlineGoogle Scholar42. StefaniniDameshekChatterjeaAdelsonMednicoff MWJBEIB: Studies on platelets. IX. Observations on the properties and mechanism of action of a potent platelet agglutinin detected in the serum of a patient with idiopathic thrombocytopenic purpura (with a note on the pathogenesis of the disease), Blood 8: 26-64 (Jan.) 1953. CrossrefMedlineGoogle Scholar43. Doan CA: Hypersplenism, Bull. New York Acad. Med. 25: 625-650 (Oct.) 1949. MedlineGoogle Scholar44. StefaniniChatterjeaDameshekZannosSantiago MJBWLEP: Studies on platelets. II. The effect of transfusion of platelet-rich polycythemic blood on the platelets and hemostatic function in "idiopathic" and "secondary" thrombocytopenic purpura, Blood 7: 53-76 (Jan.) 1952. CrossrefMedlineGoogle Scholar45. SpragueHarringtonLangeShapleigh CCWJRDJB(a) : Platelet transfusions and the pathogenesis of idiopathic thrombocytopenic purpura, J. A. M. A. 150: 1193-1198 (Nov. 22) 1952. (b) Tullis, J. L., and Rochow, E. G.: Non-wettable surfaces, Blood 7: 850-853 (Aug.) 1952. CrossrefMedlineGoogle Scholar46. Tullis JL: Separation and purification of leukocytes and platelets, Blood 7: 891-896 (Sept.) 1952. CrossrefMedlineGoogle Scholar47. HunterRoss OBJB: Newer methods of detection of incompatibilities in blood transfusion, Am. J. Clin. Path. 23: 27-32 (Jan.) 1953. CrossrefMedlineGoogle Scholar48. Williams RJ: Individual metabolic patterns and human disease: an exploratory study utilizing predominantly paper chromatographic methods, Biochemical Institute Studies IV, 1951, The University of Texas, Austin, Texas. Google Scholar49. Osgood EE: Marrow cultures, in A symposium on the blood and blood-forming organs, 1939, University of Wisconsin Press, Madison, pp. 219-241. Google Scholar50. OsgoodLiTiveyDuerstSeaman EEJGHMLAJ(a) : Growth of human leukemic leucocytes in vitro and in vivo as measured by uptake of P32 in desoxyribose nucleic acid, Science 114: 95-98 (July 27) 1951. (b) Osgood, E. E., Tivey, H., Davison, K. B., Seaman, A. J., and Li, J. G.: The relative rates of formation of new leukocytes in patients with acute and chronic leukemias: measured by the uptake of radioactive phosphorus in the isolated desoxyribosenucleic acid, Cancer 5: 331-335 (Mar.) 1952. CrossrefMedlineGoogle Scholar51. Jacobson LO: Evidence for a humoral factor (or factors) concerned in recovery from radiation injury: a review, Cancer Research 12: 315-325 (May) 1952. MedlineGoogle Scholar52. BorsookDeasyHaagen-SmitKeighleyLowy HCLAJGPH: Incorporation in vitro of labeled amino acids into proteins of rabbit reticulocytes, J. Biol. Chem. 196: 669-694 (June) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*From the Symposium on Anemia presented at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 17, 1953.From the Division of Experimental Medicine, University of Oregon Medical School, Portland, Oregon. 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