Abstract
Many drugs and substances are associated with headache, although this does not prove causality. Headache can be precipitated by acute exposure to vasodilators, non-steroidal anti-inflammatory drugs and alcohol. Drugs are also associated with intracranial hypertension (e.g. tetracyclines) and aseptic meningitis (e.g. azathioprine), where headache is a major symptom. Headaches may also be precipitated by the excessive use or the withdrawal of certain drugs. We review the current evidence for drug-related headache, and, where possible, discuss underlying mechanisms
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