Drug entrapment and release from multilamellar and reverse-phase evaporation liposomes

Abstract

The entrapment of sodium cromoglycate was determined in multilamellar liposomes prepared from natural and synthetic phospholipids. Drug entrapment was low, but was increased by inclusion of cholesterol or stearylamine into vesicle bilayers. Reverse-phase evaporation vesicles entrapped greater amounts of drug than multilamellar liposomes of the same composition. The rate of drug efflux from liposomes was determined in vitro and was dependent upon bilayer composition and the method of preparation.