Abstract
The “drug novelty hypothesis” was tested directly by giving rats experience with intraperitoneal injections of ethanol on days prior to avoidance training. This preavoidance experience with ethanol was found to eliminate the prolonged extinction of avoidance responding observed after a single exposure to ethanol. It is suggested that these findings confirm the novelty hypothesis in an active avoidance situation. Possible mechanisms of the drug novelty effect were discussed.
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