Drug Delivery Systems to the Posterior Segment of the Eye: Implants and Nanoparticles

Abstract

Intraocular diseases in some cases lead to surgical treatment of posterior segments of the eye. In addition, lack of effective treatment culminates in partial or complete blindness in patients. Drug delivery systems have succeed to overcome anatomic and physiologic barriers and have developed efficacious treatment and targeted delivery of drugs to the posterior segments of the eye. In the field of drug delivery, nanostructured drug delivery systems are proposed to be able to defeat ocular barriers, target retina, and increase the amount of permeated drug with a controlled-release delivery. In this study, we outlined several drug delivery systems for the back of the eye, and available pathways including implants and nanostructures. These systems efficiently transport drugs to the posterior eye.