Drug delivery of indomethacin in use nature starch based nanocompositehydrogel in vitro

Abstract

In this research, a novel nanocompositehydrogel based on starch have been prepared via graft copolymerization of acrylic acid (AA) and 2-hydroxyethylmetacrylate (HEMA) in the presence of montmorillonite (MMT) as nanoclay and using methylene bisacrylamide (MBA) as crosslinking agent and ammonium persulfate (APS) as initiator. The nanocompositehydrogel structure was confirmed using fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and x-ray diffraction (XRD). The effect of solutions with different pHs on the swelling of the nanocomposite hydrogel, so swelling pulsatile behavior was recorded at pH 8. In the second step of ourresearch indomethacin drug dissolving in water, were trapped on to synthesized nanocomposite hydrogel and release drug was investigated in simulated inviromental of the stomach and intestine by in vitro tests (temprature 37 o C and pH= 1.6 and 7.4). Results indicated that drug delivery in pH=7.4 (inviromental intestine) was more than pH=1.6 (inviromental stomach). The pH-sensitive nanocomposite hydrogels system is widely used inthe preparation of controlled release oral drug used.