Abstract
Cancer is one of the most serious health problems and the second leading cause of death worldwide, and with an ageing and growing population, problems related to cancer will continue. In the battle against cancer, many therapies and anticancer drugs have been developed. Chemotherapy and relevant drugs are widely used in clinical practice; however, their applications are always accompanied by severe side effects. In recent years, the drug delivery system has been improved by nanotechnology to reduce the adverse effects of the delivered drugs. Among the different candidates, core–sheath nanofibres prepared by coaxial electrospinning are outstanding due to their unique properties, including their large surface area, high encapsulation efficiency, good mechanical property, multidrug loading capacity, and ability to govern drug release kinetics. Therefore, encapsulating drugs in coaxial electrospun nanofibres is a desirable method for controlled and sustained drug release. This review summarises the drug delivery applications of coaxial electrospun nanofibres with different structures and drugs for various cancer treatments.
Highlights
Cancer is one of the leading causes of death and one of the most important barriers to extending life expectancy in most regions around the world
The application of chemotherapy is usually limited by the harm to normal tissues, which is caused by the lack of tumour selectivity and suppression of the immune system [4]
The release behaviour of the nanofibres was highly related to artificial gateways instead of polymer properties to avoid an initial burst release. This system was evaluated by encapsulating rhodamine B (Rh-B) as a drug model in the core, and the result illustrated loaded onto the fibres simultaneously, and they were annealed using a solvent vapor technique in order to be inserted onto the surface
Summary
Cancer is one of the leading causes of death and one of the most important barriers to extending life expectancy in most regions around the world. Several techniques, such as emulsion processes, phase separation, spray drying, and electrospinning, have been proposed to be effective in site-specific drug delivery [12,13]. The concept that only spinnable materials can be utilised is broken during the process of using liquids that lack spinnability via the use of modified coaxial electrospinning, which generates more possibilities for multifunctional nanofibres [20]. All of these advantages show the potential of coaxial electrospun nanofibres as promising drug delivery systems.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
