Abstract
The problem of patients not following drug therapy has long been recognized. Having reviewed studies which attempted to quantify the problem, determine its causes and advise about its management, Sacket concluded that the magnitude of compliance as a problem in clinical and health care is matched by the extent of our ignorance of its determinants and remedies. He defined compliance as the extent to which a person‘s behaviour coincides with medical or health advice. This definition has been used widely since.
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