Drug combination in vivo using combination index method: Taxotere and T607 against colon carcinoma HCT-116 xenograft tumor in nude mice

Jianing Fu,Ning Zhang,Joseph H Chou,Gudrun S Ulrich-Merzenich,Hua-Jin Dong,Shu-Fu Lin,Ting-Chao Chou

doi:10.1016/j.synres.2016.06.001

Drug combination in vivo using combination index method: Taxotere and T607 against colon carcinoma HCT-116 xenograft tumor in nude mice

Jianing Fu, Ning Zhang + Show 5 more

https://doi.org/10.1016/j.synres.2016.06.001

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Journal: Synergy	Publication Date: Jun 30, 2016
Citations: 55

Affiliation: Columbia University Irving Medical Center, Renji Hospital, Shanghai Jiao Tong University, Massachusetts General Hospital, Harvard University, Chang Gung University, Chang Gung Memorial Hospital, Memorial Sloan Kettering Cancer Center

#Combination Index #Median-effect Equation + Show 8 more

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Abstract The median-effect equation (MEE) of the mass-action law and the combination index (CI) theorem have been used for quantitative determination of synergism (CI 1) and additive effect (CI = 1) in animals in vivo. Experimental design, the theoretical algorithm and the CompuSyn software simulation have been used to illustrate step-by-step for the combination of two anti-cancer agents, Taxotere and T607 compound, with similar mode of actions of targeting microtubule polymerization, but with distinct chemical structures. These two compounds acted synergistically against human colon carcinoma HCT-116 xenograft tumor in athymic nude mice. In all, only 78 nude mice have been used. The synergy is especially significant (p

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