Abstract
An enzyme called ADAM10 cleaves a protein found in synaptic membranes, creating a soluble factor that can fuel the growth of brain tumors. Blocking this enzyme shrinks tumors in xenograft models of pediatric glioblastoma and diffuse intrinsic pontine glioma, two brain cancers with few to no effective drug options, researchers reported at the American Academy of Neurology 2017 Annual Meeting.
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