Abstract
Drug-Associated Giant Cell Arteritis with Scalp Necrosis After Treatment with Pembrolizumab: a Case Report
Highlights
A 90-year-old male with a history of hypertension was diagnosed with metastatic melanoma and treated with pembrolizumab intravenously every three weeks
We report a case of a patient who developed Giant cell arteritis (GCA) and subsequent scalp necrosis after the initiation of immunotherapy with the checkpoint inhibitor pembrolizumab for the treatment of metastatic melanoma
The patient was started on high-dose prednisone (60mg) with a taper, he was continued on treatment with pembrolizumab for metastatic melanoma as previously outlined
Summary
A 90-year-old male with a history of hypertension was diagnosed with metastatic melanoma and treated with pembrolizumab intravenously every three weeks. Giant cell arteritis (GCA) can be a rheumatologic complication of checkpoint inhibitor immunotherapy for the treatment of cancer. A rare and serious manifestation of GCA is scalp necrosis. We report a case of a patient who developed GCA and subsequent scalp necrosis after the initiation of immunotherapy with the checkpoint inhibitor pembrolizumab for the treatment of metastatic melanoma.
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