Abstract
Studies were begun to determine the process(es) by which drugs may be absorbed from the rectum, and the effect of suppository dosage form on these process(es). Using dogs, whose anatomy closely resembles that of humans, plasma salicylate levels from salicylic acid and sodium salicylate incorporated into four different suppository bases were studied. It was found that the drugs were released and absorbed equally well from cocoa butter, while from a base composed of a mixture of synthetic glycerides, a polyethylene glycol base, and from polyoxyethylene (4) sorbitan monostearate, salicylic acid gave higher plasma salicylate levels. A passive diffusion process is proposed. In the studies to follow, the effect of suppository base and physicochemical characteristics of the drugs on absorption from the rectum will be explored in detail.
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