Drotrecogin alfa (activated) did not reduce mortality at 28 or 90 days in patients with septic shock

Abstract

ACP Journal Club21 August 2012Drotrecogin alfa (activated) did not reduce mortality at 28 or 90 days in patients with septic shockChristian Brun-Buisson, MDChristian Brun-Buisson, MDCHU Henri Mondor, AP-HP, Créteil, France (C.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-4-201208210-02011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationRanieri VM, Thompson BT, Barie PS, et al; PROWESS-SHOCK Study Group. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012;366:2055-64. https://pubmed.ncbi.nlm.nih.gov/22616830Clinical Impact RatingsHospitalists: Infectious Disease: Critical Care: References1 Bernard GR, Vincent JL, Laterre PF, et al; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699-709. [PMID: 11236773] Google Scholar2 Nadel S, Goldstein B, Williams MD, et al; REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet. 2007;369:836-43. [PMID: 17350452] Google Scholar3 Abraham E, Laterre PF, Garg R, et al; Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med. 2005;353:1332-41. [PMID: 16192478] Google Scholar Author, Article, and Disclosure InformationAuthors: Christian Brun-Buisson, MDAffiliations: CHU Henri Mondor, AP-HP, Créteil, France (C.B.)This article was published at Annals.org on 7 August 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 August 2012Volume 157, Issue 4Page: JC2-11KeywordsDrugsHemorrhageMortalityResuscitationSaline solutionsSepsisSerious adverse eventsShockVasopressorsWeaning ePublished: 21 August 2012 Issue Published: 21 August 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...