Abstract
Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and even-skipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks.
Highlights
The eukaryotic genomes sequenced far have shown that substantial portions of them are formed by transposable elements (TEs)
We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes
We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks
Summary
The eukaryotic genomes sequenced far have shown that substantial portions of them are formed by transposable elements (TEs). We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. The hobo element of Drosophila has TFBSs for some master developmental genes and is potentially able to produce remarkable mutations.
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