Abstract
Nervoussystemregulateshomeostasisandadaptationtoenvironmentalchangesofawholeorgan-ism, thus deregulation of nervous processes accelerates aging (Alcedo et al., 2013a,b). The agingprocess in different models is associated with progressive degeneration of the nervous system (Leeet al., 2000) and progression of age-related neurodegenerative diseases such as Alzheimer’s dis-ease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (Boerrigter et al.,1992; Coppede and Migliore, 2010). The neurodegeneration also characterizes the progeroid syn-dromes,includingHutchinson-GilfordsyndromeandWerner’ssyndrome(CoppedeandMigliore,2010).Drosophila melanogaster is a good model organism to study age-related neurodegenerativechanges (Lu and Vogel, 2009). Enrichment in mutants with neurodegeneration among flies withshortened lifespan has been reported (Buchanan and Benzer, 1993; Kretzschmar et al., 1997). Thebrain from old flies demonstrates the ultrastructural neurodegenerative changes such as reductionin the number of synapses, defects in mitochondria, and increase in neuronal apoptosis (Had-dadietal.,2014).However,anti-aginginterventionsmaypostponetheneurodegeneration(Bgatovaet al., 2015).Here we consider molecular genetic changes in the Drosophilaaging brain and the bases forapplying the brain as a target for anti-aging intervention.
Highlights
Nervous system regulates homeostasis and adaptation to environmental changes of a whole organism, deregulation of nervous processes accelerates aging (Alcedo et al, 2013a,b)
What are the genes that change the expression level during brain aging? As it is shown in (Girardot et al, 2006) the main effect is down regulation of genes involved in synaptic transmission at different levels divided into three subgroups
On the one side of the nervous system is one of the targets of aging process and the state of nervous system may be regarded as a marker of aging
Summary
Nervous system regulates homeostasis and adaptation to environmental changes of a whole organism, deregulation of nervous processes accelerates aging (Alcedo et al, 2013a,b). The aging process in different models is associated with progressive degeneration of the nervous system (Lee et al, 2000) and progression of age-related neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (Boerrigter et al, 1992; Coppede and Migliore, 2010). Drosophila melanogaster is a good model organism to study age-related neurodegenerative changes (Lu and Vogel, 2009). Anti-aging interventions may postpone the neurodegeneration (Bgatova et al, 2015). We consider molecular genetic changes in the Drosophila aging brain and the bases for applying the brain as a target for anti-aging intervention
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
