Drosophila melanogaster genome: Correlation of chromatin state with splicing and transcription regulation

Abstract

A number of chromatin characteristics of exon regions have been revealed by analysis of chromatin modifications. The distribution of histone modifications in exon regions greatly varies among cell types. The correlation of the rate of alternative splicing with a certain chromatin type has been analyzed, and its most characteristic types have been identified. The distribution of chromatin labels in the DScam gene, which produces an enormous number of transcripts, assessed at 38000, is presented as an example. It is concluded that this gene undergoes integrated regulation by the chromatin state at the levels of domains and exons.