Abstract
Recent studies show that both cellular and humoral aspects of innate immunity play important roles during tumor progression. These interactions have traditionally been explored in vertebrate model systems. In recent years, Drosophila has emerged as a genetically tractable model system for studying key aspects of tumorigenesis including proliferation, invasion, and metastasis. The absence of adaptive immunity in Drosophila provides a unique opportunity to study the interactions between innate immune system and cancer in different genetic contexts. In this review, I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK, and JAK-STAT, microbial infection and inflammation during tumor progression.
Highlights
I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK, and JAK-STAT, microbial infection and inflammation during tumor progression
Several recent studies report that at least some aspects of the relationship between the immune system and cancer are conserved in flies (Pastor-Pareja et al, 2008; Apidianakis et al, 2009; Cordero et al, 2010; Bangi et al, 2012): Drosophila immune system recognizes and responds to tumors and this response can be tumor promoting or tumor suppressive depending on the genetic composition of the tumor
In Drosophila, this innate immune response is mediated by two pathways: Recognition of Gram positive bacteria and fungi depends on secreted factors that regulate the processing and activation of the Toll receptor ligand Spatzle (Spz) (Lemaitre et al, 1996)
Summary
I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK, and JAK-STAT, microbial infection and inflammation during tumor progression. Several recent studies report that at least some aspects of the relationship between the immune system and cancer are conserved in flies (Pastor-Pareja et al, 2008; Apidianakis et al, 2009; Cordero et al, 2010; Bangi et al, 2012): Drosophila immune system recognizes and responds to tumors and this response can be tumor promoting or tumor suppressive depending on the genetic composition of the tumor.
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